![]() In addition, cAMP binds to and regulates the function of ion channels such as the HCN channels and a. Other data are presented that are consistent with the conclusion that cyclic AMP inhibits glucose transport into adipocytes. Taken together, these results suggest that cyclic AMP is a mediator of the actions of glucagon on enterocytes and provide further evidence for a role of cyclic AMP in the modulation of sugar transport across the intestinal enterocyte. It is also involved in the activation of protein kinases. Paolo Tortora, Nedda Burlini, Flavio Leoni and Andrea Guerritore. The response to glucagon and cyclic AMP appears to be caused by a decrease in Na+ permeability of the mucosal membrane. Dependence on cyclic AMP of glucose-induced inactivation of yeast gluconeogenetic enzymes. Treatment with glucagon or cyclic AMP resulted in significant hyperpolarization of the potential difference across the brush-border membrane, an important driving force for Na(+)-sugar cotransport. Incubation of isolated enterocytes with pancreatic glucagon at concentrations known to stimulate sugar transport by these cells significantly increased enterocyte levels of cyclic AMP. Cyclic AMP and insulin release Abstract The role of cyclic adenosine-3,5-monophosphate (cAMP) for insulin secretion has been investigated. In turn, the absence of cAMP results in a failure to. ![]() Glucose uptake by basolateral vesicles was increased at low, but not at high sugar concentrations. Specifically, the catabolites produced by the breakdown of glucose prevent production of a signal molecule called cyclic AMP (cAMP). Brush-border vesicles derived from enterocytes incubated with cyclic AMP and theophylline accumulated significantly more glucose over a wide range of sugar concentrations, suggesting a change in maximum velocity of the transport system. ![]() In order to study further the effects of cyclic AMP on this process, we have measured glucose accumulation by brush-border and basolateral membrane vesicles prepared from villus enterocytes following exposure of these cells to cyclic AMP and theophylline. Although the involvement of the adenylate cyclase system with glucose transport in the small intestine is poorly understood, there is increasing evidence that cyclic AMP stimulates sugar uptake. ![]()
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